Brent M.KiousAmanda V.Bakian
Volume 288, June 2020, 112990
https://www.sciencedirect.com/science/a ... 34h0ZIkSF0We examined the risk of tardive dysphoria—the delayed onset of negative emotional symptoms such as depression attributed to antidepressant exposure—in persons taking antidepressants with no recorded history of psychiatric illness.
Exposure to antidepressants for migraine prophylaxis was not associated with a significantly increased risk of depression or anxiety, suggesting that tardive dysphoria did not occur.
However, antidepressant discontinuation was significantly associated with an increased risk of receiving a new diagnosis of a depressive disorder in patients not known to have any prior history of psychiatric illness.